Daunorubicin hydrochloride for injection msds msdsdigital. Mar 19, 2020 daunorubicin hydrochloride must not be used if the cumulative highest dose of daunorubicin hydrochloride 500600 mgm 2 in adults, 300 mgm 2 in children of 2 years and older, 10mgkg body weight in children under 2 years or another cardiotoxic anthracycline has already been previously administered, as otherwise the danger of lifethreatening. This medication is given by injection into a vein by a health care professional. This product can expose you to chemicals including daunorubicin hydrochloride, which is known to the state of california to cause reproductive toxicity with developmental. Daunorubicin forms complexes with dna by intercalation between base. Home cas database listed 2 daunorubicin hydrochloride material safety data sheetmsds cas no. Daunorubicin injection must be given in a hospital or medical facility under the supervision of a doctor who is experienced in giving chemotherapy medications for cancer. Cerubidine daunorubicin hydrochloride is the hydrochloride salt of an anthracycline cytotoxic antibiotic produced by a strain of streptomyces coeruleorubidus. Solutions of daunorubicin should be freshly prepared. The product catalog provides you with a full listing of tevas brand and generic product lines.
Daunorubicin may cause serious or lifethreatening heart problems at any time during your treatment or months to years after your treatment has ended. Product information daunorubicin injection page 4 of 8 supersedes. Biochemphysiol actions on binding to dna, daunomycin intercalates, with its daunosamine. See actual entry in rtecs for complete information. Buy dnarna synthesis inhibitor daunorubicin hydrochloride daunomycin hydrochloride from abmole bioscience. Citations are publications that use tocris products. Doxorubicin hydrochloride solution for injection 2 mgml. Selected citations for daunorubicin hydrochloride include. Daunorubicin hcl hazardous combustion products thermal decomposition or combustion products may include the following substances.
Disclaimer the sds samples above are collected from the internet by chemblink and displayed here for the tutorial purpose only. Product monograph cerubidine daunorubicin hydrochloride. It is also used as an effective chemotherapeutic agent against tumors especially acute myeloid leukaemia and acute lymphocytic leukaemia. Jul 15, 2019 a only for patients failing to achieve a response with the first induction cycle for the first cycle of induction, the recommended dose of vyxeos is daunorubicin 44 mgm 2 and cytarabine 100 mgm 2 liposome administered via intravenous infusion over 90 minutes on days 1, 3, and 5.
Daunorubicin hydrochloride must not be used if the cumulative highest dose of daunorubicin hydrochloride 500600 mgm 2 in adults, 300 mgm 2 in children of 2 years and. Upon intercalation, daunorubicin forms stable complexes with the. It must neverbe given by the intramuscular or subcutaneous route. Daunorubicin contains daunorubicin hydrochloride as the active ingredient equivalent to 2 mg of daunorubicin in each ml of injection. Daunorubicin exhibits anticancer chemotherapeutic activity and is clinically used to treat various cancers, including neuroblastoma and acute myelogenous leukemia aml. Advice for firefighters special protective equipment for firefighters wear positivepressure selfcontained breathing apparatus scba and. Daunorubicin hydochloride and daunomycin are other names for daunorubicin. Daunorubicin 20mg powder for injection summary of product. It also contains sodium chloride and water for injections. Since the growth of normal body cells may also be affected by daunorubicin, other effects will also occur.
Daunorubicin hydrochloride is a potent bone marrow suppressant. Cerubidine daunorubicin hcl for injection rx only warning 1. Daunorubicin hydrochloride is contraindicated in patients who have shown a hypersensitivity to it. Daunorubicin hydrochloride united states pharmacopeia usp. Cerubidine must be given into a rapidly flowing intravenous infusion. Daunorubicin hydrochloride for injection special notice. Daunorubicin, also known as daunomycin, is a chemotherapy medication used to treat cancer. Daunorubicin hydrochloride and cytarabine liposome is also being studied in the treatment of other types of cancer. Find medication information including related drug classes, side effects, patient statistics and answers to frequently asked questions. Cerubidine daunorubicin hydrochloride for injection. Lithium silicide in contact with hydrogen chloride.
Suppression will occur in all patients given a therapeutic dose of this drug. Verify drug name and dose prior to preparation and administration to avoid. Daunorubicin hydrochloride and cytarabine liposome. Calcium carbide reacts with hydrogen chloride gas with incandescence. Dailymed daunorubicin hydrochloride injection, solution. Hydrochloric acid no data available water for injection doxorubicin hydrochloride revision date. Daunomycin hydrochloride, daunorubicin hydrochloride cas number 23541506. Apexbio daunorubicin hcldna topoisomerase ii inhibitor. Material may be irritating to the mucous membranes and upper respiratory tract. Quantities above 1 g may be subject to additional shipping fees.
Daunorubicin hcl according to regulation ec no 19072006, annex ii, as amended. Daunorubicin can affect the metabolism and synthesis of dna and rna. Daunorubicin hydrochloride is used in photostability, antileukemic, and drug metabolism studies. Achemblock offers h8446, daunorubicin hydrochloride for your research.
Daunorubicin hydrochloride drug information chemocare. Only select registry of toxic effects of chemical substances rtecs data is presented here. Identification of the substancemixture and of the companyundertaking 1. Aug 03, 2012 cerubidine daunorubicin may also inhibit polymerase activity, affect regulation of gene expression, and produce free radical damage to dna. Daunorubicin hcl is an inhibitor of dna topoisomerase ii 1. Daunorubicin hydrochloride safety data sheet section 2. Daunorubicin is an antineoplastic in the anthracycline class. Toxicity data the meaning of any abbreviations which appear in this section is. Page 2 of 9 physical and chemical description daunorubicin r. Daunorubicin injection is a sterile, isotonic, preservative free solution containing daunorubicin hydrochloride 2. Daunorubicin hydrochloride is used in photostability, antileukemic, and drug.
A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin. Dosage is based on your medical condition, body size, and response to treatment. Specifically it is used for acute myeloid leukemia aml, acute lymphocytic leukemia all, chronic myelogenous leukemia cml, and kaposis sarcoma. Daunorubicin hydrochloride cas 23541506 scbt santa. Inquire about dmf, cgmp, price, availability, samples, sourcing, purity and more. It intercalates between base pairs and interacts wi daunorubicin hydrochloride, 23541506. Daunorubicin hydrochloride mouse oral ld50 205 mgkg iarc. Dec 17, 2012 daunorubicin hydrochloride is a potent bone marrow suppressant. Daunorubicin hydrochloride proposition 65 warnings website. Nikolskaya e, sokol m, faustova m, zhunina o, mollaev m, yabbarov n, tereshchenko o, popov r, severin e. Daunomycin effectively binds to every 3 base pairs which causes unwinding. Daunorubicin hydrochloride daunomycin hydrochloride cas. Daunorubicin hydrochloride investigated as a drug and mutagen. Daunorubicin hydrochloride for injection uses, side effects.
A liposomal formulation known as liposomal daunorubicin. Biochemphysiol actions on binding to dna, daunomycin intercalates, with its daunosamine residue directed toward the minor groove. Daunorubicin has antimitotic and cytotoxic activity through a number of proposed mechanisms of action. Upon intercalation, daunorubicin forms stable complexes with the dna backbone, inhibiting normal functioning of the double helix and the proteins that interact with it.
More about daunorubicin hydrochloride and cytarabine liposome. Sds of daunorubicin hydrochloride, safety data sheets, cas. Daunorubicin is an anthracycline drug used that killing cells by inhibiting dna and rna synthesis. Indications daunorubicin is an anthracycline glycoside antibiotic and a potent antileukaemic agent. This product can expose you to chemicals including daunorubicin hydrochloride, which is are known to the state of california to cause birth defects or other reproductive harm. Daunorubicin belongs to the group of cancerfighting medicines known as antineoplastics, and specifically to the family of antineoplastics called anthracyclines. Product identifier product name daunorubicin hcl product number md11679 synonyms. This product can expose you to chemicals including daunorubicin hydrochloride, which is known to the state of california to cause reproductive toxicity with developmental effects. Safety data sheet according to federal register vol.
Find products priceavailability, shipping time in our secure ecommerce website. Daunorubicin hydrochloride for injection msds special notice. This document has been prepared in accordance with standards for workplace safety, which require the inclusion of all known hazards of the active substance or its intermediates regardless of the. Apexbio daunorubicin hcldna topoisomerase ii inhibitorcas. Daunorubicin hydrochloride cas 23541506 msds download. Material safety data sheet of daunorubicin hydrochloride abmole. Treat as potentially hazardous toxicology not fully investigated. It is also used as an effective chemotherapeutic agent against tumors especially.
Rubidium acetylene carbides burns with slightly warm hydrochloric acid. It is recommended to check the blood uric acid and urea levels three or four times a week during the first week. Doxorubicin hydrochloride investigated as a drug, mutagen, natural product, reproductive effector, and tumorigen. Daunorubicin daunorubicin hydrochloride drug medicine. Empirical formula hill notation c 27 h 29 no 10 hcl. The catalog displays all strengths and sizes along with the description, imprint code, ndc and. Daunorubicin hydrochloride united states pharmacopeia usp reference standard synonym. The catalog displays all strengths and sizes along with the description, imprint code, ndc and photo for each product. The comparative study of influence of lactic and glycolic acids copolymers type on properties of daunorubicin loaded nanoparticles and drug release. Drug name active ingredients strength dosage formroute marketing status te code rld rs. Daunorubicin fda prescribing information, side effects. Product information daunorubicin injection page 1 of 8. Commission regulation eu no 2015830 of 28 may 2015. Jan 01, 2017 daunorubicin belongs to the general group of medicines known as antineoplastics.
Material safety data sheet of daunorubicin hydrochloride. Daunorubicin hydrochloride for injection revision date. Therapy with daunorubicin hydrochloride should not be started in patients with preexisting druginduced bone marrow suppression unless the benefit from such treatment warrants the risk. Daunorubicin hcl inhibits both dna and rna synthesis and inhibits dna synthesis with ki of 0.
Uranium phosphide reacts with hydrochloric acid to release spontaneously flammable phosphines. Daunorubicin hydrochloride is a dna intercalating anthracylcine natural product isolated from streptomyces peucetius. Daunorubicin hydrochloride 98% cas 23541506 achemblock. Daunorubicin is a microcrystalline orangered hygroscopic sterile powder supplied in vials containing the equivalent of 20mg daunorubicin as hydrochloride and mannitol as a stabilising agent. Daunorubicin hcl is a water soluble anthracycline chemotherapeutic agent produced by streptomyces coeruleorubidus this product is considered a dangerous good. Cerubidine daunorubicin possesses an antitumor effect against a wide spectrum of animal tumors, either grafted or spontaneous. Daunorubicin seems to interfere with the growth of cancer cells, which are eventually destroyed. Doxorubicin hydrochloride injection safety data sheet sds. Daunorubicin hydrochloride solution for injection drug summary.
Definition from the nci drug dictionary detailed scientific definition and other names for this drug. In combination with other antineoplastics in the treatment of leukemias. Daunorubicin hydrochloride monograph for professionals. Dailymed vyxeos daunorubicin and cytarabine liposome.
Vyxeos has different dosage recommendations than daunorubicin hydrochloride injection, cytarabine injection, daunorubicin citrate liposome injection, and cytarabine liposome injection. Doxorubicin hydrochloride injection athenex pharmaceuticals. Daunorubicin is an anthracycline first produced by streptomyces. In some cases, health care professionals may use the trade name cerubidine or other names.
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